Traditional clinical trials have long served as the cornerstone of medical research, providing essential evidence for evaluating the safety and efficacy of new interventions. However, these trials often encounter significant challenges, including inefficiencies, high costs, logistical complexities, and limited participant diversity. Post the COVID-19 pandemic era, a groundbreaking approach called decentralized clinical trials (DCTs) has emerged as the new normal, harnessing technological advancements to revolutionize the landscape of medical research. This article explores the principles, key
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Medicine is the testament to the virtue of human innovation - a collective desire to reduce the burden of disease and an ever evolving journey to enhance the quality of human health. The origin of medicines can be traced back to ancient times when human began to use the natural resources to treat injuries and illness. Highly developed and documented evidences of medicinal practices comes from the world’s most ancient civilisations such as Egypt, India, China and Greece1. Traditional Chinese medicine2, which dates back more than 2,500 years, used a combination of herbs, acupuncture, and other
Artificial intelligence is a field of engineering and science that focus on making intelligent machines. Artificial intelligence is a top technology that is reshaping the pharmaceutical industry's future. For ages, the pharmaceutical industry has been developing cures and treatments. Traditionally, medication design and manufacture took many years, extensive clinical studies, and sky-high prices.This has been changing with the advancement of 21st-century technology. We will see different drug designs, manufacturing, and clinical trials in the future.
Natural Language Processing (NLP), Mach
Natural Language Processing (NLP), Mach
The drug business has various strange qualities that make it very different from individuals' thought process of as industry. Its additionally an industry packed with logical inconsistencies; for instance, notwithstanding the undisputed reality that for more than a century the business has made a major contribution to human prosperity and the decrease of chronic sickness and suffering, it is still routinely recognized bygeneral society in assessment reviews as one of the most un-confided in ventures, frequently being contrasted horribly with the atomic business. It is without a doubt perhaps
Many Pharma companies in EU suffer a size problem. When revenues are below 100 M€ is extremely difficult to survive in a market where to renew the portfolio is increasingly costly, as well as to pay the regulatory demands, which grow year by year (environmental regulations, verification, wastes processing, plastics control, etc...). Additionally, the easy solution of playing in the Generics Market does not work anymore, mostly due to the devastating price erosion in major markets (France, Germany, Italy and Spain).
Cannabis plants contain a wide variety of complex compounds including phytocannabinoids, terpenoids and flavonoids, found mainly in the inflorescences. Major phytocannabinoids like CBD and ∆9-THC have beneficial effects on human health. It is well known that variations in their profiles are connected to growth, light quality, humidity, the use of pesticides, harvesting and especially post-harvesting, like improper drying procedures that can facilitate fungal and microbial growth. Mass spectrometry is the tool of choice for the analysis of all these biologically active compounds along with tha
The spleen is an organ found in all vertebrates. It is a large secondary lymphoid organ that primarily functions as a blood filter. The second spleen’s function is immune system surveillance. As a specialized immune organ, the spleen plays a significant role in innate and adaptive immunity. Specifically, the spleen is a crucial organ for peripheral immune tolerance, complementing central immune tolerance. Splenectomy in both study animals and humans results in overwhelming infections with especially, encapsulated bacteria [1]. On the opposite, supporting the immune system with an additional s
A countless number of proteins including growth factors receptors, and cytokines play a pivotal role during the onset and exacerbation of numerous human diseases including cancer, autoimmune and inflammatory disorders.1
Of these proteins, extracellular and membrane-associated proteins represent around 40% of human proteome and they play diversified roles including signal transduction, cell adhesion, cell-cell interaction, and solute transport. Accordingly, the vast majority (ca. 60%) of current therapeutic approaches; such as small molecule inhibitors, oligonucleotide agents and monoclonal a
Of these proteins, extracellular and membrane-associated proteins represent around 40% of human proteome and they play diversified roles including signal transduction, cell adhesion, cell-cell interaction, and solute transport. Accordingly, the vast majority (ca. 60%) of current therapeutic approaches; such as small molecule inhibitors, oligonucleotide agents and monoclonal a
Cancer is considered as a common name to address a large group comprising more than 100 diseases affecting several parts of the body. All cancers show common characteristics such as the uncontrolled growth and proliferation of abnormal cells, infiltrating and spreading to different tissues and organs throughout the body, and destroying the normal cells and tissues. Cancer can begin in the epithelial tissue and is known as carcinomas, and when it begins in the connective or supportive tissue, they are called sarcomas. The blood cancers are known as leukemias, and when it begins in the plasma c
This article explores the profound impact of bioinformatics in the realm of precision oncology, revolutionising the understanding, diagnosis, and treatment of cancer. Bioinformatics, a multidisciplinary field, bridges the gap between vast biological datasets and meaningful insights, enabling personalised therapies and groundbreaking discoveries. However, challenges in data integrity, reproducibility, and infrastructure must be overcome to fully realise it’s potential. Bioinformatics stands as a beacon of hope, ushering in an era where cancer is decoded at its molecular core, promising improve
More than 60% of survey respondents indicated that they favor establishing new facilities or revamping existing facilities with expansion plans over the next few years. Preference for a new facility is driven by the fact that mRNA does not require an extensive setup or that there would be no excess capacity to convert. Other respondents would prefer to update and utilise existing facilities for the pilot phase of development and, in some cases, only establish new facilities after the approval of the vaccine. For mRNA vaccines, the barrier to adoption is the lack of experience with this modali
Human and veterinary antimicrobial misuse is one of the cornerstone drivers of antimicrobial resistance (AMR) leading to a rapidly drying up of the antibiotic pipeline. In 2010, the Indian subcontinent was adjudicated to be the world’s largest consumer of antibiotics and hence curbing injudicious use of antibiotics was a must. The current drivers of AMR include veterinary, human, biomedical waste and from innate evolutionary genetical factors leading to the genesis of the menacing MDR, XDR and PDR strains seen worldwide. High grade of evidence now underscores the necessity for antimicrobial s
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